A skin regeneration therapy using autologous dermal fibroblasts cultured in the clinic's in-house CPC and administered to the skin, with the clinic director overseeing both patient care and cell quality control.
The treatment promotes the production of collagen and elastin to improve wrinkles and skin laxity, helping to achieve natural skin rejuvenation.

Motif Ginza Clinic's Autologous Cultured Dermal Fibroblast Therapy is a regenerative medicine treatment provided as private medical care. Dermal fibroblasts collected from the patient's own skin are cultured in the clinic's in-house Cell Processing Center (CPC) and then administered to the skin.

Dermal fibroblasts are cells located in the dermis that play a key role in maintaining the skin's structural foundation by producing collagen, elastin, and other extracellular matrix components.

This therapy may be considered for concerns such as wrinkles, skin laxity, photoaging, loss of skin firmness, and acne scars. A physician will evaluate each patient and determine whether the treatment is appropriate.

At our clinic, the entire process—from tissue collection and cell culture to quality control and administration—is managed within the in-house CPC. The clinic director personally oversees both patient care and the verification of cell quality.

At Motif Ginza Clinic, we offer highly safe regenerative medicine using the patient’s own cells. For treating skin aging, such as wrinkles and sagging, we utilize fibroblasts. Our advanced in-house cell culture facility enables us to expand the cells and reintroduce them into the body, reducing the risks of rejection or allergic reactions and minimizing potential side effects. From cell extraction to cultivation and administration, our fully integrated in-house system ensures flexible, reliable, and trustworthy medical care.

Program details

【Treatment Schedule】
Day 1
Medical consultation
Eligibility assessment
Skin tissue collection

After Tissue Collection
Dermal fibroblasts are cultured in the clinic's in-house CPC for approximately 4–5 weeks

After Cell Culture
Cells are administered to the skin according to the treatment purpose, such as:
The entire face
Around the eyes
Both cheeks

After Treatment
Follow-up evaluation as needed
The period from tissue collection to cell administration will be individually scheduled based on the cell culture progress and the clinic's appointment availability.

Providing Medical Institution

Motif GINZA Clinic.

〒104-0061
4th Floor and 9th Floor, Ginza Kawai Building, 1-7-6 Ginza, Chuo-ku Tokyo

https://regenerative.motif-ginza.com/

Specialty

・Autologous adipose-derived stem cell therapy for chronic pain
・Autologous adipose-derived stem cell therapy for osteoarthritis
・Autologous adipose-derived stem cell therapy for skin aging and photoaging
・NK cell therapy for cancer treatment, cancer prevention, and improvement of immune function
・Autologous adipose-derived stem cell therapy for alopecia
・Autologous adipose-derived stem cell therapy for type 2 diabetes mellitus and prediabetes
・Autologous adipose-derived stem cell therapy for atherosclerosis
・Autologous adipose-derived stem cell therapy for menopausal disorders and decreased ovarian function

Eligibility Criteria/Exclusions for Treatment

A physician will determine whether treatment can be provided and whether the patient is eligible after reviewing the medical consultation, medical history, current medications, overall health condition, blood test results, and other relevant medical information.

The following information must be confirmed in advance:

Purpose of treatment
Target treatment area
Medical history
Current medications
Presence of infectious diseases
Use of anticoagulant medications
Possibility of pregnancy

If you plan to visit the clinic using a wheelchair, please contact the clinic in advance.

Precautions / Contraindications

Treatment may require prior evaluation or postponement depending on the presence of an infectious disease, a serious systemic medical condition, the possibility of pregnancy, the patient's medical history, current medications, or other relevant medical factors.